Breast cancer prevention

NEWS IN BRIEF — Posted April 18, 2005

Print  |   Email  |   Respond  |   Reprints  |   Like Facebook  |   Share Twitter  |   Tweet Linkedin

A new clinical trial has been launched in the United States and Canada to study the role of an aromatase inhibitor, exemestane, in the prevention of breast cancer.

The drug suppresses estrogen production, a key component in the development of some types of breast cancer. Exemestane could provide an alternative to tamoxifen, the only FDA-approved drug for the prevention of breast cancer, according to researchers.

The study, which is being coordinated by the National Cancer Institute of Canada, will follow more than 4,500 postmenopausal women from the United States, Canada and Spain over five years. The women must also have an increased risk of developing breast cancer as demonstrated by age, family history, age at first menstrual period and age at first live birth.

Aromatase inhibitors are being used to treat breast cancer in women, and results from a study published last year demonstrated that exemestane prevented the occurrence of new cancers in the opposite breast of women who have already had breast cancer, suggesting it may also be able to prevent the disease in healthy women, say researchers.

The National Cancer Institute of Canada Clinical Trials Group is based at Queen's University in Kingston, Ontario. Pfizer Inc., the manufacturer of exemestane, is providing the drug for the trial. For more information, call 800-4-CANCER.

Note: This item originally appeared at

Back to top



Read story

Confronting bias against obese patients

Medical educators are starting to raise awareness about how weight-related stigma can impair patient-physician communication and the treatment of obesity. Read story

Read story


American Medical News is ceasing publication after 55 years of serving physicians by keeping them informed of their rapidly changing profession. Read story

Read story

Policing medical practice employees after work

Doctors can try to regulate staff actions outside the office, but they must watch what they try to stamp out and how they do it. Read story

Read story

Diabetes prevention: Set on a course for lifestyle change

The YMCA's evidence-based program is helping prediabetic patients eat right, get active and lose weight. Read story

Read story

Medicaid's muddled preventive care picture

The health system reform law promises no-cost coverage of a lengthy list of screenings and other prevention services, but some beneficiaries still might miss out. Read story

Read story

How to get tax breaks for your medical practice

Federal, state and local governments offer doctors incentives because practices are recognized as economic engines. But physicians must know how and where to find them. Read story

Read story

Advance pay ACOs: A down payment on Medicare's future

Accountable care organizations that pay doctors up-front bring practice improvements, but it's unclear yet if program actuaries will see a return on investment. Read story

Read story

Physician liability: Your team, your legal risk

When health care team members drop the ball, it's often doctors who end up in court. How can physicians improve such care and avoid risks? Read story

  • Stay informed
  • Twitter
  • Facebook
  • RSS
  • LinkedIn