Avian flu vaccine elicits immune system response

NEWS IN BRIEF — Posted April 17, 2006

Print  |   Email  |   Respond  |   Reprints  |   Like Facebook  |   Share Twitter  |   Tweet Linkedin

A vaccine created from an inactivated H5N1 avian influenza virus might provide effective protection against this bug, according to a study paid for by the National Institute of Allergy and Infectious Diseases and published in the New England Journal of Medicine March 30.

Researchers randomized more than 400 healthy adults to receive either two doses of this vaccine in varying amounts or a placebo. Those who received two shots of 90 micrograms of vaccine, the highest dosage, had the most robust immune system response. Mild pain at the injection site was the most common adverse event. No severe reactions were reported.

Authors suggested lower doses of vaccine might be sufficient to generate a response capable of defending against this virus and that dose-sparing approaches should be pursued aggressively. In the case of a pandemic, it might not be possible to produce enough vaccine for everyone to receive large amounts of vaccine.

"We are working hard to address the many challenges that remain with regard to the development of an H5N1 vaccine," said NIAID Director Anthony S. Fauci, MD. "We are investigating other options that may allow us to reduce the dosage ... so we can achieve a more practical immunization strategy."

Note: This item originally appeared at

Back to top



Read story

Confronting bias against obese patients

Medical educators are starting to raise awareness about how weight-related stigma can impair patient-physician communication and the treatment of obesity. Read story

Read story


American Medical News is ceasing publication after 55 years of serving physicians by keeping them informed of their rapidly changing profession. Read story

Read story

Policing medical practice employees after work

Doctors can try to regulate staff actions outside the office, but they must watch what they try to stamp out and how they do it. Read story

Read story

Diabetes prevention: Set on a course for lifestyle change

The YMCA's evidence-based program is helping prediabetic patients eat right, get active and lose weight. Read story

Read story

Medicaid's muddled preventive care picture

The health system reform law promises no-cost coverage of a lengthy list of screenings and other prevention services, but some beneficiaries still might miss out. Read story

Read story

How to get tax breaks for your medical practice

Federal, state and local governments offer doctors incentives because practices are recognized as economic engines. But physicians must know how and where to find them. Read story

Read story

Advance pay ACOs: A down payment on Medicare's future

Accountable care organizations that pay doctors up-front bring practice improvements, but it's unclear yet if program actuaries will see a return on investment. Read story

Read story

Physician liability: Your team, your legal risk

When health care team members drop the ball, it's often doctors who end up in court. How can physicians improve such care and avoid risks? Read story

  • Stay informed
  • Twitter
  • Facebook
  • RSS
  • LinkedIn