Spleen cells may contribute to beta-cell regeneration in diabetics

NEWS IN BRIEF — Posted Dec. 18, 2006

Print  |   Email  |   Respond  |   Reprints  |   Like Facebook  |   Share Twitter  |   Tweet Linkedin

A treatment combining an immune adjuvant with cells from the spleen may help reverse type 1 diabetes, according to a technical comment published in the Nov. 24 Science.

Several previous studies have confirmed that a protocol combining Freund's complete adjuvant, which suppresses the immune cells that destroy pancreatic islets, with transplanted splenocytes can resolve this condition in mice. The reports were inconclusive, however, regarding the role these spleen cells played in this recovery.

According to this paper, surrounding endogenous cells appeared to be the source of the revived islets but that the transplanted cells hastened the recovery.

"It is still early, but it appears that there are multiple potential sources for regenerating islets," said Denise Faustman, MD, PhD, lead author and director of the Immunobiology Laboratory at Massachusetts General Hospital in Boston. "As a research community we should pursue all avenues. We're excited to see what will happen in humans."

Note: This item originally appeared at

Back to top



Read story

Confronting bias against obese patients

Medical educators are starting to raise awareness about how weight-related stigma can impair patient-physician communication and the treatment of obesity. Read story

Read story


American Medical News is ceasing publication after 55 years of serving physicians by keeping them informed of their rapidly changing profession. Read story

Read story

Policing medical practice employees after work

Doctors can try to regulate staff actions outside the office, but they must watch what they try to stamp out and how they do it. Read story

Read story

Diabetes prevention: Set on a course for lifestyle change

The YMCA's evidence-based program is helping prediabetic patients eat right, get active and lose weight. Read story

Read story

Medicaid's muddled preventive care picture

The health system reform law promises no-cost coverage of a lengthy list of screenings and other prevention services, but some beneficiaries still might miss out. Read story

Read story

How to get tax breaks for your medical practice

Federal, state and local governments offer doctors incentives because practices are recognized as economic engines. But physicians must know how and where to find them. Read story

Read story

Advance pay ACOs: A down payment on Medicare's future

Accountable care organizations that pay doctors up-front bring practice improvements, but it's unclear yet if program actuaries will see a return on investment. Read story

Read story

Physician liability: Your team, your legal risk

When health care team members drop the ball, it's often doctors who end up in court. How can physicians improve such care and avoid risks? Read story

  • Stay informed
  • Twitter
  • Facebook
  • RSS
  • LinkedIn