Sequential therapy more effective for eradicating H. pylori

NEWS IN BRIEF — Posted June 2, 2008

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Administering a set sequence of proton pump inhibitors and antibiotics is more effective at eliminating Helicobacter pylori than taking all these drugs together, according to a meta-analysis published online last month in the Annals of Internal Medicine.

Researchers pooled 10 randomized controlled trials studying the two approaches in 2,747 treatment-naïve patients. Seven days of PPI drugs accompanied by two antibiotics eradicated H. pylori in nearly 77% of patients, but five days of a PPI and one antibiotic followed by another five days of a PPI and two antibiotics accomplished this in more than 93% of patients.

The authors are calling for additional randomized trials comparing sequential therapy to PPI-based quadruple therapy or longer-term standard therapy before it becomes more common.

"If such [randomized controlled trials] confirm superiority of sequential therapy over existing treatment regimens, it could becomes standard treatment," wrote the authors.

Note: This item originally appeared at

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