Reproductive medicine guidelines called effective
■ A study notes a decline in multiple births suggests that further regulation of assisted reproduction is not needed.
By Andis Robeznieks — Posted May 10, 2004
On the heels of a report from the President's Council on Bioethics calling for more self-regulation in the medical field of assisted reproduction, a study published in the New England Journal of Medicinesuggested not only is the field already engaging in self-regulation, but it's working.
Specifically, the study noted that since the American Society for Reproductive Medicine issued guidelines in 1998 aimed at lowering the number of multiple births created by assisted reproduction embryo-transfer techniques, the percentage of pregnancies with three or more fetuses has "significantly decreased."
"It looked like it [the decrease] was at least associated with recent changes in the guidelines," said Mark D. Hornstein, MD, one of the study's authors and director of the division of reproductive medicine at Brigham and Women's Hospital, Boston.
Dr. Hornstein and the study's lead author, Tarun Jain, MD, a reproductive endocrinologist at Brigham and Women's Hospital, said the study was not a reply to the bioethics council's March report, "Reproduction and Responsibility: The Regulation of New Biotechnologies."
"The timing turned out to be serendipitous but advantageous to the body of work getting noticed," Dr. Jain said.
Costs and health risks associated with multiple births prompted the ASRM to develop guidelines on the number of embryos transferred. Using data from the Centers for Disease Control and Prevention, researchers found that the number of embryos transferred has decreased since then, with the steepest decline between 1998 and 1999 (11.1%). Simultaneously, the number of multiple births also declined, with a 20.8% decrease reported between 1998 and 1999.
The study noted that Brazil, Denmark, Germany, Hungary, Saudi Arabia, Singapore, Sweden, Switzerland and the United Kingdom have strict laws limiting the number of embryos that can be used per pregnancy cycle. Dr. Hornstein said early drafts of the Bioethics Council report suggested legislation may be necessary in the United States, but this was toned down in the final version.
ASRM spokesman Sean Tipton noted that the success of the guidelines is something that should be recognized by doctors in all fields.
"It's another piece of evidence that it's physicians who ought to be making medical decisions, not insurance companies, not legislators -- not even bioethicists," Tipton said.