Smart pill sends message when medication is swallowed

Its creators hope it can make clinical trials cheaper and increase patient prescription compliance.

By — Posted May 10, 2010

Print  |   Email  |   Respond  |   Reprints  |   Like Facebook  |   Share Twitter  |   Tweet Linkedin

University of Florida researchers think they might have a solution to the seemingly intractable problem of monitoring prescription adherence: a "tattletale pill" that can alert physicians when it's been swallowed.

The system attaches a microchip and digestible antenna to a standard-size capsule. When the pill is swallowed, it communicates with a small electronic device carried by the patient. That device in turn signals a cell phone or laptop, informing doctors or family members.


A new "tattletale pill" puts a microchip and digestible antenna on a standard-size capsule to tell doctors that the pill has been swallowed. Rizwan Bashirullah, PhD, assistant professor of electrical and computer engineering at the University of Florida, helped develop the pill. Photo by Ray Carson / University of Florida News Bureau

The Florida researchers say such a system could make clinical trials more efficient by alleviating the need to have researchers watch every participant take every pill.

If trial subjects are noncompliant, "you can't correlate the outcome of the study with the efficacy of the drug itself. So that requires additional time, excess patients, a lot of money -- tens of millions of dollars," said Rizwan Bashirullah, PhD, assistant professor of electrical and computer engineering at the University of Florida, who helped develop the device. "So the real question is, if you can use this technology and improve compliance by a little bit, even a few percentage points, it could have an impact which eventually gets translated to the consumer and insurers."

The device could also be used in clinical practice, Bashirullah said, by giving physicians an accurate read on whether prescriptions are being filled and taken. "You can envision it having an impact if this picks up for the elderly, mental health or addiction patients."

When patients don't follow a prescription order as written, costs can mount to $100 billion a year for avoidable hospitalizations and more than 200,000 deaths annually, various studies have found.

In a study published online Feb. 4 by the Journal of General Internal Medicine, researchers, looking at nearly 200,000 prescriptions written by 1,217 prescribers over 12 months, found that 18% of new prescriptions were never filled. Other studies have put noncompliance rates -- either from not filling a prescription or failing to take the medication as prescribed -- as high as half of all prescriptions, depending on the population.

The Florida researchers developed a way to print nontoxic, conductive silver lines on the outside of a capsule to serve as an antenna for the microchip embedded inside. Once swallowed, the microchip, via the antenna, sends its message that the pill has been taken.

Bashirullah said the pill has tested successfully on artificial models and cadavers. After breaking down, it leaves only a small byproduct of silver, less than what is present in tap water, he said.

The university has created a spin-off company that hopes to take the device to market. Bashirullah said the next step is obtaining FDA approval, which will require more rigorous testing of the pill system.

In terms of potential pricing, Bashirullah compared it to radio frequency identification technology. Now that RFID tags are in the mass market, they can be purchased for as little as 25 cents. Once the pill technology is produced in high volumes, "there's no reason we couldn't use the same [pricing] model," he said.

Bashirullah expects the system to go to market in about two years. It's not expected to replace other strategies to address medication adherence, which Bashirullah notes is a complex problem that should be addressed with a multipronged approach. The system could be used in conjunction with other strategies such as patient education, complimentary technologies or better labeling, he said.

An editorial published online April 7 by the New England Journal of Medicine suggested that financial incentives, such as reducing co-payments for patients and changing the physician payment structure so doctors get rewarded for compliance, could help improve adherence rates. The piece also recommended strategies to identify which patients are most likely to be noncompliant, which can help in developing corrective strategies.

Back to top

External links

"Primary Medication Non-Adherence; Analysis of 195,930 Electronic Prescriptions," abstract, Journal of General Internal Medicine, Feb. 4 (link)

"Patients' Question-Asking Behavior During Primary Care Visits: A Report From the AAFP National Research Network," abstract, Annals of Internal Medicine, March/April (link)

"Thinking Outside the Pillbox -- Medication Adherence as a Priority for Health Care Reform," New England Journal of Medicine, published online April 7 (link)

Back to top



Read story

Confronting bias against obese patients

Medical educators are starting to raise awareness about how weight-related stigma can impair patient-physician communication and the treatment of obesity. Read story

Read story


American Medical News is ceasing publication after 55 years of serving physicians by keeping them informed of their rapidly changing profession. Read story

Read story

Policing medical practice employees after work

Doctors can try to regulate staff actions outside the office, but they must watch what they try to stamp out and how they do it. Read story

Read story

Diabetes prevention: Set on a course for lifestyle change

The YMCA's evidence-based program is helping prediabetic patients eat right, get active and lose weight. Read story

Read story

Medicaid's muddled preventive care picture

The health system reform law promises no-cost coverage of a lengthy list of screenings and other prevention services, but some beneficiaries still might miss out. Read story

Read story

How to get tax breaks for your medical practice

Federal, state and local governments offer doctors incentives because practices are recognized as economic engines. But physicians must know how and where to find them. Read story

Read story

Advance pay ACOs: A down payment on Medicare's future

Accountable care organizations that pay doctors up-front bring practice improvements, but it's unclear yet if program actuaries will see a return on investment. Read story

Read story

Physician liability: Your team, your legal risk

When health care team members drop the ball, it's often doctors who end up in court. How can physicians improve such care and avoid risks? Read story

  • Stay informed
  • Twitter
  • Facebook
  • RSS
  • LinkedIn